Since a few decades one can recognize a continuous boom of Complementary Alternative Medicine (CAM). Against this background in the present manuscript the conceptual, historical and methodical requirements of the so-called Apitherapy, which has been in an institutionalization process since approximately four decades ago, are investigated. As one result of these investigations the bee venom therapy is here characterized as the real root of this relative new stream within the natural medicine. Its history and theory will be exposed in detail in a following article.